RESTful framework for collaborative internet of things based on IEC 61850

El contenido de los capítulos 2 y 3 está sujeto a confidencialidad 161 p.En 1991, Mark Weiser formuló el paradigma de Computación Ubicua definiendo el concepto de Entorno Inteligente como un espacio físico repleto de dispositivos, muy integrados en el entorno, y con capacidades de identificación, sensorización y actuación. Internet de las Cosas (IoT) expande el ámbito de localización de estos dispositivos y servicios ubicuos, representados como cosas, de un entorno local a internet como red global. Para la implementación de estos escenarios de aplicación, la colaboración entre las cosas es uno de los principales retos de investigación. El objetivo de esta colaboración es ser capaces de satisfacer necesidades globales mediante la combinación de servicios individuales. Esta Tesis propone una arquitectura colaborativa entre las cosas desplegadas en internet.Las tecnologías alrededor de los Servicios Web SOAP/XML, adecuadas para IoT, soportan aspectos claves para un sistema colaborativo como la publicación, descubrimiento, control y gestión de eventos de los dispositivos. Como alternativa, REST ha ganado terreno en este ámbito por ser considerada una opción más ligera, sencilla y natural para la comunicación en internet. Sin embargo, no existen protocolos para descubrimiento y gestión de eventos para recursos REST. Esta Tesis aborda dicha carencia proponiendo una especificación de estos protocolos para arquitecturas REST. Otro aspecto importante es la representación, a nivel de aplicación, de las cosas distribuidas. Entre las propuestas para la estandarización de los modelos de información y comunicación en este dominio que podrían aplicarse, de manera similar, a IoT, destaca el estándar IEC 61850. Sin embargo, los protocolos de comunicación definidos por el estándar no son adecuados para IoT. Esta Tesis analiza la idoneidad del IEC 61850 para escenarios IoT y propone un protocolo de comunicación REST para sus servicios.Por último, se trata la problemática asociada a la confiabilidad que debe proporcionar una arquitectura IoT para dominios de aplicación relacionados con la salud o sistemas de seguridad funcional (Safety)

RESTful framework for collaborative internet of things based on IEC 61850

El contenido de los capítulos 2 y 3 está sujeto a confidencialidad 161 p.En 1991, Mark Weiser formuló el paradigma de Computación Ubicua definiendo el concepto de Entorno Inteligente como un espacio físico repleto de dispositivos, muy integrados en el entorno, y con capacidades de identificación, sensorización y actuación. Internet de las Cosas (IoT) expande el ámbito de localización de estos dispositivos y servicios ubicuos, representados como cosas, de un entorno local a internet como red global. Para la implementación de estos escenarios de aplicación, la colaboración entre las cosas es uno de los principales retos de investigación. El objetivo de esta colaboración es ser capaces de satisfacer necesidades globales mediante la combinación de servicios individuales. Esta Tesis propone una arquitectura colaborativa entre las cosas desplegadas en internet.Las tecnologías alrededor de los Servicios Web SOAP/XML, adecuadas para IoT, soportan aspectos claves para un sistema colaborativo como la publicación, descubrimiento, control y gestión de eventos de los dispositivos. Como alternativa, REST ha ganado terreno en este ámbito por ser considerada una opción más ligera, sencilla y natural para la comunicación en internet. Sin embargo, no existen protocolos para descubrimiento y gestión de eventos para recursos REST. Esta Tesis aborda dicha carencia proponiendo una especificación de estos protocolos para arquitecturas REST. Otro aspecto importante es la representación, a nivel de aplicación, de las cosas distribuidas. Entre las propuestas para la estandarización de los modelos de información y comunicación en este dominio que podrían aplicarse, de manera similar, a IoT, destaca el estándar IEC 61850. Sin embargo, los protocolos de comunicación definidos por el estándar no son adecuados para IoT. Esta Tesis analiza la idoneidad del IEC 61850 para escenarios IoT y propone un protocolo de comunicación REST para sus servicios.Por último, se trata la problemática asociada a la confiabilidad que debe proporcionar una arquitectura IoT para dominios de aplicación relacionados con la salud o sistemas de seguridad funcional (Safety)

Amphiphilic Acrylic Nanoparticles Containing the Poloxamer Star Bayfit® 10WF15 as Ophthalmic Drug Carriers

Topical application of drops containing ocular drugs is the preferred non-invasive route to treat diseases that a_ect the anterior segment of the eye. However, the formulation of eye drops is a major challenge for pharmacists since the access of drugs to ocular tissues is restricted by several barriers. Acetazolamide (ACZ) is a carbonic anhydrase inhibitor used orally for the treatment of ocular hypertension in glaucoma. However, large ACZ doses are needed which results in systemic side e_ects. Recently, we synthesized copolymers based on 2-hydroxyethyl methacrylate (HEMA) and a functionalized three-arm poloxamer star (Bayfit-MA). The new material (HEMA/Bayfit-MA) was engineered to be transformed into nanoparticles without the use of surfactants, which represents a significant step forward in developing new ophthalmic drug delivery platforms. Acetazolamide-loaded nanocarriers (ACZ-NPs) were prepared via dialysis (224 +/- 19 nm, ̶ 17.2 +/- 0.4 mV). The in vitro release rate of ACZ was constant over 24 h (cumulative delivery of ACZ: 83.3 +/- 8.4%). Following standard specifications, ACZ-NPs were not cytotoxic in vitro in cornea, conjunctiva, and macrophages. In normotensive rabbits, ACZ-NPs generated a significant intraocular pressure reduction compared to a conventional solution of ACZ (16.4% versus 9.6%) with the same dose of the hypotensive drug (20 μg). In comparison to previously reported studies, this formulation reduced intraocular pressure with a lower dose of ACZ. In summary, HEMA:Bayfit-MA nanoparticles may be a promising system for ocular topical treatments, showing an enhanced ocular bioavailability of ACZ after a single instillation on the ocular surface

Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study

There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality

Ruxolitinib in refractory acute and chronic graft-versus-host disease : a multicenter survey study

Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. First-line treatment is based on the use of high doses of corticosteroids. Unfortunately, second-line treatment for both acute and chronic graft-versus-host disease, remains a challenge. Ruxolitinib has been shown as an effective and safe treatment option for these patients. Seventy-nine patients received ruxolitinib and were evaluated in this retrospective and multicenter study. Twenty-three patients received ruxolitinib for refractory acute graft-versus-host disease after a median of 3 (range 1-5) previous lines of therapy. Overall response rate was 69.5% (16/23) which was obtained after a median of 2 weeks of treatment, and 21.7% (5/23) reached complete remission. Fifty-six patients were evaluated for refractory chronic graft-versus-host disease. The median number of previous lines of therapy was 3 (range 1-10). Overall response rate was 57.1% (32/56) with 3.5% (2/56) obtaining complete remission after a median of 4 weeks. Tapering of corticosteroids was possible in both acute (17/23, 73%) and chronic graft-versus-host disease (32/56, 57.1%) groups. Overall survival was 47% (CI: 23-67%) at 6 months for patients with aGVHD (62 vs 28% in responders vs non-responders) and 81% (CI: 63-89%) at 1 year for patients with cGVHD (83 vs 76% in responders vs non-responders). Ruxolitinib in the real life setting is an effective and safe treatment option for GVHD, with an ORR of 69.5% and 57.1% for refractory acute and chronic graft-versus-host disease, respectively, in heavily pretreated patients

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO

Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO

Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary file